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Synergistic agents for tumor-specific therapy mediated by focused ultrasound treatment
Biomaterials Science ( IF 6.6 ) Pub Date : 2020-11-14 , DOI: 10.1039/d0bm01364a
Wonseok Choi 1 , Chulhong Kim
Affiliation  

This minireview highlights the recent advances in the therapeutic agents that aim to provide synergistic enhancements of focused ultrasound treatment of tumors. Even though focused ultrasound therapy itself can bring therapeutic effects in cancers, many biochemical agents have been reported in the literature to enhance the treatment efficacy significantly. Until now, many mechanisms have been researched to advance the therapy, such as sonodynamic-plus-chemo-therapy, microbubble-aided therapy, localized release or delivery of nanomaterials, and multimodal image-guided therapy. Here, the novel materials adopted in each mechanism are briefly reviewed to provide a trend in the field and encourage future research towards the successful deployment of focused ultrasound therapy in real clinical environments.

中文翻译:

聚焦超声治疗介导的肿瘤特异性治疗的协同剂

本综述重点介绍了旨在提供协同增强肿瘤聚焦超声治疗的治疗剂的最新进展。尽管聚焦超声疗法本身可以为癌症带来治疗效果,但文献中已经报道了许多生化剂以显着提高治疗效果。到目前为止,已经研究了许多机制来推进治疗,例如声动力加化疗、微泡辅助治疗、纳米材料的局部释放或递送以及多模式图像引导治疗。在这里,简要回顾了每种机制中采用的新型材料,以提供该领域的趋势并鼓励未来的研究,以在真实临床环境中成功部署聚焦超声治疗。
更新日期:2020-12-16
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