In this work, Ni-doped ZrO₂ nanoparticles (NPs) were used to decorate multi-walled carbon nanotubes (MWCNTs) to obtain a Ni-ZrO₂/MWCNT nanocomposite, which acted as an efficient electrode material for the highly sensitive electrochemical detection of the anti-inflammatory drug 5-amino salicylic acid (5-ASA). The Ni-ZrO₂ NPs were obtained through a facile co-precipitation method, and the subsequent support of these Ni-ZrO₂ NPs onto MWCNTs was accomplished via an ultrasonication technique. Supporting Ni-ZrO₂ NPs on MWCNTs not only results in excellent catalytic properties, but it also substantially enhances the surface area, electrical conductivity, and electron transfer process. The electrochemical activity of the synthesized Ni-ZrO₂/MWCNT nanocomposite was systematically investigated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The constructed Ni-ZrO₂/MWCNT-modified glassy carbon (GC) electrode manifests superior electrocatalytic oxidation activity toward 5-ASA, with a lower peak potential compared with Ni-ZrO₂-NP- and MWCNT-modified GC electrodes. Importantly, the proposed biosensor exhibited excellent sensitivity during the detection of 5-ASA with a wide linear concentration range (0.001–500 μM) and a low detection limit of 0.0029 μM. Moreover, the biosensor demonstrated excellent repeatability, reproducibility, stability, and high specificity toward 5-ASA detection in the presence of different interfering species. Furthermore, the biosensor showed satisfactory recovery rates in complex biological samples, such as human blood serum, human urine, and 5-ASA tablet samples.

中文翻译：

---

Ni掺杂的ZrO2纳米粒子修饰了MW-CNT纳米复合材料，用于高灵敏度电化学检测5-氨基水杨酸

在这项工作中，掺Ni的ZrO ₂纳米颗粒（NPs）用于装饰多壁碳纳米管（MWCNTs），以获得Ni-ZrO ₂ / MWCNT纳米复合材料，可作为高效电极材料，用于高灵敏的电化学检测。抗炎药5-氨基水杨酸（5-ASA）。Ni-ZrO ₂ NPs通过简便的共沉淀法获得，随后将这些Ni-ZrO ₂ NPs负载在MWCNTs上是通过超声技术完成的。支持Ni-ZrO ₂MWCNTs上的NPs不仅具有出色的催化性能，而且还大大提高了表面积，电导率和电子转移过程。通过循环伏安法（CV）和微分脉冲伏安法（DPV）对合成的Ni-ZrO ₂ / MWCNT纳米复合材料的电化学活性进行了系统研究。所构建的Ni-ZrO ₂ / MWCNT修饰的玻碳（GC）电极对5-ASA表现出优异的电催化氧化活性，与Ni-ZrO ₂相比具有较低的峰值电势-NP和MWCNT修饰的GC电极。重要的是，提出的生物传感器在5-ASA的检测中表现出出色的灵敏度，具有宽的线性浓度范围（0.001–500μM）和0.0029μM的低检测限。此外，在存在不同干扰物种的情况下，该生物传感器对5-ASA检测具有极好的可重复性，可重复性，稳定性和高特异性。此外，该生物传感器在复杂的生物样品（例如人血清，人尿和5-ASA片剂样品）中显示出令人满意的回收率。