Septic shock (SS) leads to a high mortality rate for sepsis patients. Norepinephrine (NE) is a preferred vasoactive agent in SS treatment. This study aimed to assess the effects of NE at different administration time and NE combined with SP treatment on the cardiac function and prognosis of SS.

SS patients received NE treatment at different administration time and NE combined with SP treatment were enrolled in this study. The serum levels of cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP), ejection fraction (EF), and pressure-adjusted heart rate (PAR) value were analyzed to evaluate cardiac function. The 28-day survival information was collected and assessed using the Kaplan-Meier method and log-rank test.

The cardiac function of SS patients was improved significantly by NE treatment, especially in the patients received NE at 2 h after fluid infusion, which evidenced by the increased BNP and cTnI levels and EF% and the decreased RAP. In the NE-2 h group, SS patients had a better 28-day survival rate compared with those patients in NE-1 h and -3 h groups. Furthermore, the significantly improved cardiac function and survival outcomes were found in patients received NE combined SP treatment.

Taken together, this study results show that NE administration at 2 h after fluid infusion may be the optimal time point for the treatment of SS and NE combined with SP treatment can improve early cardiac dysfunction and 28-day survival outcomes in patients with SS.

脓毒症休克 (SS) 导致脓毒症患者的高死亡率。去甲肾上腺素 (NE) 是 SS 治疗中优选的血管活性剂。本研究旨在评估不同给药时间NE及NE联合SP治疗对SS心功能及预后的影响。

SS患者在不同给药时间接受NE治疗，NE联合SP治疗入选本研究。分析血清心肌肌钙蛋白 I (cTnI) 和 B 型利钠肽 (BNP)、射血分数 (EF) 和压力调整心率 (PAR) 值以评估心脏功能。使用 Kaplan-Meier 方法和对数秩检验收集和评估 28 天生存信息。

NE治疗显着改善SS患者的心功能，特别是在输液后2小时接受NE的患者，BNP和cTnI水平和EF％升高，RAP降低。与NE-1 h和-3 h组患者相比，NE-2 h组SS患者的28天生存率更高。此外，在接受 NE 联合 SP 治疗的患者中发现了显着改善的心脏功能和生存结果。

综上所述，本研究结果表明，输液后 2 h 给予 NE 可能是治疗 SS 的最佳时间点，NE 联合 SP 治疗可以改善 SS 患者的早期心功能障碍和 28 天生存结果。