Breath acetone (BrAce) is a validated biomarker of lipid oxidation and has been extensively studied for many applications, such as monitoring ketoacidosis in diabetes, guiding ketogenic diet, and measuring fat burning during exercise. Although many sensors have been reported for BrAce measurement, most of the contributions tested only synthetic or spiked breath samples, because of the complex components of human breath. Here, we show that online accurate detection of BrAce can be achieved using a colorimetric sensor. The high selectivity is enabled by the specific reaction between acetone and hydroxylamine sulfate, and the sensor has a high agreement with a reference instrument in ketosis monitoring. We anticipate that the colorimetric acetone sensor can be applied to various health-related applications.

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在线检测呼吸丙酮的比色传感器

呼吸丙酮（BrAce）是一种经过验证的脂质氧化生物标志物，已被广泛研究用于许多应用，例如监测糖尿病中的酮症酸中毒，指导生酮饮食和测量运动中的脂肪燃烧。尽管已经报道了许多用于BrAce测量的传感器，但是由于人类呼吸的复杂成分，大多数贡献仅测试了合成的或加标的呼吸样品。在这里，我们显示可以使用比色传感器实现BrAce的在线精确检测。丙酮和硫酸羟胺之间的特定反应可实现高选择性，并且该传感器在酮症监测中与参考仪器具有很高的一致性。我们期望比色丙酮传感器可以应用于各种与健康相关的应用。