Abstract

The tumor microenvironment contains many cellular components influencing tumor behaviors, such as metastasis, angiogenesis and chemo-resistance. Tumor-associated macrophages (TAMs) are one of such components that can also manipulate the overall prognosis and patient survival. Analysis of tumor-macrophage crosstalk is crucial as tumor cells can polarize circulatory monocytes into TAMs. Such trans-polarization of macrophages support tumor mediated evasion and suppression of immune response. Additionally, such TAMs significantly influence tumor growth and proliferation, making them a potential candidate for precision therapeutics. However, the failure of macrophage-dependent therapies at clinical trials emphasizes the fault in current perception and research modality. This review discussed this field’s progress regarding emerging model systems with a focused view on the in vitro platforms. The inadequacy of currently available models and their implications on existing studies also analyzed. The need for a conceptual and experimental leap toward a human-relevant in vitro custom-built platform for studying tumor-macrophage crosstalk is acknowledged.

中文翻译：

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肿瘤巨噬细胞串扰：如何倾听

摘要

肿瘤微环境包含许多影响肿瘤行为的细胞成分，例如转移、血管生成和化学抗性。肿瘤相关巨噬细胞 (TAM) 是此类成分之一，也可以操纵整体预后和患者存活率。肿瘤-巨噬细胞串扰的分析至关重要，因为肿瘤细胞可以将循环单核细胞极化为 TAM。巨噬细胞的这种跨极化支持肿瘤介导的免疫反应的逃避和抑制。此外，此类 TAM 显着影响肿瘤生长和增殖，使其成为精准治疗的潜在候选者。然而，巨噬细胞依赖疗法在临床试验中的失败凸显了当前认知和研究模式的缺陷。体外平台。还分析了当前可用模型的不足及其对现有研究的影响。承认需要在概念和实验上飞跃到与人类相关的体外定制平台来研究肿瘤-巨噬细胞串扰。