Understanding the interaction between human genome regulatory elements and transcription factors is fundamental to elucidate the structure of gene regulatory networks. Here we present CONREL, a web application that allows for the exploration of functionally annotated transcriptional ‘consensus’ regulatory elements at different levels of abstraction. CONREL provides an extensive collection of consensus promoters, enhancers and active enhancers for 198 cell-lines across 38 tissue types, which are also combined to provide global consensuses. In addition, 1000 Genomes Project genotype data and the ‘total binding affinity’ of thousands of transcription factor binding motifs at genomic regulatory elements is fully combined and exploited to characterize and annotate functional properties of our collection. Comparison with other available resources highlights the strengths and advantages of CONREL. CONREL can be used to explore genomic loci, specific genes or genomic regions of interest across different cell lines and tissue types. The resource is freely available at https://bcglab.cibio.unitn.it/conrel.

中文翻译：

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使用 CONREL 探索功能注释的转录一致调控元件

了解人类基因组调控元件和转录因子之间的相互作用是阐明基因调控网络结构的基础。在这里，我们介绍了 CONREL，这是一个 Web 应用程序，它允许在不同抽象层次上探索功能注释的转录“共识”调控元素。CONREL 为 38 种组织类型的 198 种细胞系提供了广泛的共识启动子、增强子和活性增强子，它们也被结合起来提供全球共识。此外，1000 Genomes Project 基因型数据和数千个转录因子结合基序在基因组调控元件上的“总结合亲和力”被充分结合并被利用来表征和注释我们集合的功能特性。与其他可用资源的比较突出了 CONREL 的优势和优势。CONREL 可用于探索不同细胞系和组织类型的基因组位点、特定基因或感兴趣的基因组区域。该资源可在 https://bcglab.cibio.unitn.it/conrel 上免费获得。