Abstract

Bioactive peptides are compounds hydrolysed from an inactive parental protein that has beneficial effects on health, such as reduction of blood pressure, antioxidant activity, reduction of problems caused by diabetes, anticancer action, among others. These compounds can be obtained by the hydrolysis of proteins by enzymes, as the proteases, which are produced by microorganisms through solid-state fermentation. Solid-state fermentation (SSF) has been widely used to produce enzymes and other biocompounds due to advantages as simplicity, the possibility of using residues as substrates, allowing the reduction of environmental pollution, the addition of value to these residues, and lower costs in the process. SSF also allows the simultaneous production of proteases and bioactive peptides, optimising the process and reducing antinutritional compounds, such as allergens. This work aimed to review the literature on the production of proteases and bioactive peptides through solid-state fermentation, including the simultaneous production of these compounds, since the fermented medium can benefit from the hydrolysis capacity of the enzymes produced by microorganisms. Normally, obtaining these compounds has been studied in an isolated way and not concomitantly in a single bioprocess, being this the main differential of our review.

摘要

生物活性肽是从无活性的母体蛋白质水解的化合物，对健康具有有益作用，例如降低血压、抗氧化活性、减少由糖尿病引起的问题、抗癌作用等。这些化合物可以通过酶水解蛋白质获得，如蛋白酶，由微生物通过固态发酵产生。固态发酵 (SSF) 因其简单、可以使用残留物作为底物、减少环境污染、增加这些残留物的价值以及降低成本等优点而被广泛用于生产酶和其他生物化合物。过程。SSF 还允许同时生产蛋白酶和生物活性肽，优化工艺并减少抗营养化合物，比如过敏原。这项工作旨在回顾有关通过固态发酵生产蛋白酶和生物活性肽的文献，包括同时生产这些化合物，因为发酵培养基可以受益于微生物产生的酶的水解能力。通常，获得这些化合物是以孤立的方式研究的，而不是在单一的生物过程中同时研究，这是我们审查的主要区别。