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The Hippocampus and Dorsolateral Striatum Integrate Distinct Types of Memories through Time and Space, Respectively
Journal of Neuroscience ( IF 5.3 ) Pub Date : 2020-11-18 , DOI: 10.1523/jneurosci.1084-20.2020
Janina Ferbinteanu

Several decades of research have established that different kinds of memories result from the activity of discrete neural networks. Studying how these networks process information in experiments that target specific types of mnemonic representations has provided deep insights into memory architecture and its neural underpinnings. However, in natural settings reality confronts organisms with problems that are not neatly compartmentalized. Thus, a critical problem in memory research that still needs to be addressed is how distinct types of memories are ultimately integrated. Here we demonstrate how two memory networks, the hippocampus and dorsolateral striatum, may accomplish such a goal. The hippocampus supports memory for facts and events, collectively known as declarative memory and often studied as spatial memory in rodents. The dorsolateral striatum provides the basis for habits that are assessed in stimulus–response types of tasks. Expanding previous findings, the current work revealed that in male Long–Evans rats, the hippocampus and dorsolateral striatum use time and space in distinct and largely complementary ways to integrate spatial and habitual representations. Specifically, the hippocampus supported both types of memories when they were formed in temporal juxtaposition, even if the learning took place in different environments. In contrast, the lateral striatum supported both types of memories if they were formed in the same environment, even at temporally distinct points. These results reveal for the first time that by using fundamental aspects of experience in specific ways, the hippocampus and dorsolateral striatum can transcend their attributed roles in information storage.

SIGNIFICANCE STATEMENT The current paradigm in memory research postulates that different types of memories reflected in separate types of behavioral strategies result from activity in distinct neural circuits. However, recent data have shown that when rats concurrently acquired in the same environment of hippocampal-dependent spatial navigation and striatal-dependent approach of a visual cue, each of the two types of memories became dependent on both the hippocampus and dorsolateral striatum. The current work reveals that the hippocampus and dorsolateral striatum use distinct and complementary principles to integrate different types of memories in time and space: the hippocampus integrates memories formed in temporal proximity, while the lateral striatum integrates memories formed in the same space.



中文翻译:

海马和背外侧纹状体分别通过时间和空间整合不同类型的记忆

几十年的研究已经确定,离散神经网络的活动会导致不同类型的记忆。在针对特定类型的助记符表示的实验中研究这些网络如何处理信息,为内存结构及其神经基础提供了深刻的见解。但是,在自然环境中,现实面对的是生物,它们的问题并不是整齐划一的。因此,在存储器研究中仍然需要解决的一个关键问题是如何最终整合不同类型的存储器。在这里,我们演示了两个记忆网络(海马和背外侧纹状体)如何实现这一目标。海马支持对事实和事件的记忆,统称为声明性记忆,通常在啮齿动物中被研究为空间记忆。背外侧纹状体为在刺激-反应类型任务中评估的习惯提供了基础。扩大以前的发现,目前的研究表明,在雄性Long-Evans大鼠中,海马和背外侧纹状体以不同的,且基本互补的方式利用时间和空间来整合空间和习惯性表征。具体而言,即使学习是在不同的环境中进行的,海马在时间并列形成时也支持两种类型的记忆。相反,如果纹状体是在相同的环境中形成的,则即使在时间上不同的点上,横纹也支持这两种记忆。这些结果首次揭示,通过以特定方式使用经验的基本方面,

意义声明记忆研究的当前范例假定,在不同类型的行为策略中反映的不同类型的记忆是由不同神经回路中的活动引起的。然而,最近的数据表明,当大鼠在视觉提示的海马依赖性空间导航和纹状体依赖性方法的相同环境中同时捕获时,两种类型的记忆中的每一种都变得同时依赖于海马和背外侧纹状体。当前的工作表明,海马和背外侧纹状体使用截然不同的互补原理在时间和空间上整合不同类型的记忆:海马整合在时间上接近形成的记忆,而外侧纹状体整合在同一空间中形成的记忆。

更新日期:2020-11-19
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