Frequency-following responses to musical notes spanning the octave 65-130 Hz were elicited in a person with auditory neuropathy, a disorder of subcortical neural synchrony, and a control subject. No phaselocked responses were observed in the person with auditory neuropathy. The control subject had robust responses synchronized to the fundamental frequency and its harmonics. Cortical onset responses to each note in the series were present in both subjects. These results support the hypothesis that subcortical neural synchrony is necessary to generate the frequency-following response-including for stimulus frequencies at which a cortical contribution has been noted. Although auditory cortex ensembles may synchronize to fundamental frequency cues in speech and music, subcortical neural synchrony appears to be a necessary antecedent.

中文翻译：

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神经科学案例研究：皮质对频率跟随反应的贡献取决于皮质下同步

在患有听神经病、皮层下神经同步障碍和对照受试者中引发了对跨越 65-130 Hz 八度音阶音符的频率跟随反应。在患有听神经病的人中没有观察到锁相反应。控制对象具有与基频及其谐波同步的稳健响应。两个受试者都存在对系列中每个音符的皮质起始反应。这些结果支持皮层下神经同步性是产生频率跟随反应所必需的假设，包括已经注意到皮层贡献的刺激频率。尽管听觉皮层合奏可能与语音和音乐中的基本频率线索同步，但皮层下神经同步似乎是一个必要的前因。