Parasites of Leishmania genus have developed sophisticated strategies allowing them to deactivate their host macrophage to promote their survival. It has become clear that miRNAs play important roles in shaping innate and adaptive immune responses toward pathogens. It is not surprising that several pathogens including Leishmania have evolved the ability to regulate host macrophage miRNA expression in order to manipulate host cell phenotypes to their advantage. However, very little is known about the mechanisms used by intracellular pathogens to drive changes in host cell miRNA abundance. In this review, Leishmania exploitation of macrophage transcription factor c‐Myc as a critical proxy virulence factor to regulate abundance of macrophage miRNAs influencing macrophage physiology to promote its survival will be discussed.

中文翻译：

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利什曼原虫通过参与转录因子c-Myc调节宿主巨噬细胞miRNA的表达

利什曼原虫属的寄生虫已开发出复杂的策略，使它们能够灭活宿主巨噬细胞以促进其存活。显而易见的是，miRNA在塑造针对病原体的先天性和适应性免疫反应中起着重要作用。不足为奇的是，包括利什曼原虫在内的几种病原体已经进化出调节宿主巨噬细胞miRNA表达的能力，以操纵宿主细胞表型发挥其优势。但是，关于细胞内病原体用于驱动宿主细胞miRNA丰度变化的机制了解甚少。在这篇评论中，利什曼原虫 将讨论利用巨噬细胞转录因子c-Myc作为调节巨噬细胞miRNA数量的重要代理毒力因子，影响巨噬细胞生理学以促进其生存。