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Functional connectivity with the anterior and posterior hippocampus during spatial memory
Hippocampus ( IF 3.5 ) Pub Date : 2020-11-18 , DOI: 10.1002/hipo.23283
Haley A Fritch 1 , Dylan S Spets 1 , Scott D Slotnick 1
Affiliation  

Evidence of differential connectivity and activity patterns across the long-axis of the hippocampus has led to many hypotheses about functional specialization of the anterior and posterior hippocampus, including a hypothesis linking the anterior hippocampus to memory encoding and the posterior hippocampus to memory retrieval. The hippocampal encoding/retrieval and network (HERNET) model of memory predicts that encoding should engage the anterior hippocampus and the attention network, whereas retrieval should engage the posterior hippocampus and the default network. In a previous fMRI study that employed multivoxel pattern analysis, we found that the patterns of activity in the anterior hippocampus predicted the quadrant of spatial memory encoding. In the current fMRI study, we investigated whether the spatial memory encoding activity in the anterior hippocampus and retrieval activity in the posterior hippocampus had a higher degree of connectivity to the attention network or the default network. During the study phase, abstract shapes were presented in each quadrant of the visual field and participants were instructed to remember each shape's location while maintaining central fixation. During the test phase, the same shapes were presented in the center of the screen and participants identified the previous location of each shape. Generalized psychophysiological interaction analyses were conducted between the anatomically defined anterior and posterior hippocampus and the rest of the brain. This revealed preferential connectivity between the anterior hippocampus and regions of the attention network during encoding and between the posterior hippocampus and regions of the default network during retrieval. In addition, there were location-specific patterns of connectivity with the anterior hippocampus and posterior hippocampus during encoding and retrieval of right visual field items. These results suggest that the anterior and posterior hippocampus interact with regions of the attention network and default network during spatial memory encoding and retrieval, respectively, and support the HERNET model of memory.

中文翻译:

空间记忆过程中与前海马体和后海马体的功能连接

跨海马长轴的不同连接和活动模式的证据导致了许多关于前海马和后海马功能特化的假设,包括将海马前部与记忆编码和后海马体与记忆检索联系起来的假设。记忆的海马编码/检索和网络 (HERNET) 模型预测,编码应该涉及海马前部和注意力网络,而检索应该涉及海马后部和默认网络。在之前使用多体素模式分析的 fMRI 研究中,我们发现前海马体的活动模式预测了空间记忆编码的象限。在目前的 fMRI 研究中,我们研究了海马前部的空间记忆编码活动和海马后部的检索活动是否与注意力网络或默认网络具有更高程度的连接性。在研究阶段,在视野的每个象限中呈现抽象形状,并指示参与者记住每个形状的位置,同时保持中心注视。在测试阶段,相同的形状出现在屏幕的中央,参与者识别出每个形状的先前位置。在解剖学定义的前海马体和后海马体与大脑的其余部分之间进行了广义的心理生理相互作用分析。这揭示了编码期间前海马体和注意网络区域之间的优先连接,以及检索期间后海马体和默认网络区域之间的优先连接。此外,在右视野项目的编码和检索过程中,与前海马体和后海马体存在特定位置的连接模式。这些结果表明,在空间记忆编码和检索期间,前海马体和后海马体分别与注意网络和默认网络的区域相互作用,并支持记忆的 HERNET 模型。在右视野项目的编码和检索过程中,存在与前海马体和后海马体的特定位置连接模式。这些结果表明,在空间记忆编码和检索期间,前海马体和后海马体分别与注意网络和默认网络的区域相互作用,并支持记忆的 HERNET 模型。在右视野项目的编码和检索过程中,存在与前海马体和后海马体的特定位置连接模式。这些结果表明,在空间记忆编码和检索期间,前海马体和后海马体分别与注意网络和默认网络的区域相互作用,并支持记忆的 HERNET 模型。
更新日期:2020-11-18
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