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The Gut Ecosystem: A Critical Player in Stroke
NeuroMolecular Medicine ( IF 3.5 ) Pub Date : 2020-11-18 , DOI: 10.1007/s12017-020-08633-z
Rosa Delgado Jiménez 1 , Corinne Benakis 1
Affiliation  

The intestinal microbiome is emerging as a critical factor in health and disease. The microbes, although spatially restricted to the gut, are communicating and modulating the function of distant organs such as the brain. Stroke and other neurological disorders are associated with a disrupted microbiota. In turn, stroke-induced dysbiosis has a major impact on the disease outcome by modulating the immune response. In this review, we present current knowledge on the role of the gut microbiome in stroke, one of the most devastating brain disorders worldwide with very limited therapeutic options, and we discuss novel insights into the gut-immune-brain axis after an ischemic insult. Understanding the nature of the gut bacteria-brain crosstalk may lead to microbiome-based therapeutic approaches that can improve patient recovery.



中文翻译:

肠道生态系统:中风的关键参与者

肠道微生物组正在成为影响健康和疾病的关键因素。这些微生物虽然在空间上仅限于肠道,但它们正在交流和调节大脑等远处器官的功能。中风和其他神经系统疾病与破坏的微生物群有关。反过来,中风引起的生态失调通过调节免疫反应对疾病结果产生重大影响。在这篇综述中,我们介绍了目前关于肠道微生物组在中风中作用的知识,这是全球最具破坏性的脑部疾病之一,治疗选择非常有限,我们讨论了对缺血性损伤后肠-免疫-脑轴的新见解。了解肠道细菌-大脑串扰的性质可能会导致基于微生物组的治疗方法,从而改善患者的康复。

更新日期:2020-11-19
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