The green reduction of berberine (BBR) to tetrahydroberberine (THB) and dihydroberberine (DHB) was realized via ionic liquid (IL)-assisted and solvent-free synthetic technologies; and the reactive behaviour and mechanisms under related conditions were investigated in detail. In particular, a reaction in a tablet was realized through a pressing method for the first time. The performances of ten Brønsted acidic ILs in three series together with four solid-phase reactive technologies were comprehensively compared.

中文翻译：

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离子液体和无溶剂技术辅助的绿色还原过程中异喹啉生物碱的反应行为

通过离子液体（IL）辅助和无溶剂合成技术，将小ber碱（BBR）从绿色还原为四氢小ber碱（THB）和二氢小ber碱（DHB）；并详细研究了相关条件下的反应行为和机理。特别是，第一次通过压制方法实现了片剂中的反应。综合比较了十个布朗斯台德酸性ILs在三个系列中的性能以及四种固相反应技术的性能。