This paper describes the synthesis of two distinct types of CF₃-containing spirooxindoles by varying the active methylene sources. The reaction was carried out in DMSO, assisted by molecular iodine and Na₂CO₃ via systematic application of Michael reaction and iodine mediated cyclisation. With 5-methyl-2,4-dihydro-3H-pyrazol-3-one as the methylene source, the final products obtained were spirodihydrofuropyrazolyl oxindoles, whereas 1H-indene-1,3(2H)-dione as the methylene source gave the final compounds spirocyclopropyl oxindoles. Modest to good yields were obtained for both the spiro systems.

中文翻译：

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通过改变活性亚甲基源碘辅助合成 CF3 附加的螺二氢呋喃基/环丙基羟吲哚

本文描述了通过改变活性亚甲基来源合成两种不同类型的含CF _{3螺氧吲哚。}该反应在 DMSO 中进行，分子碘和 Na ₂ CO ₃ 通过系统应用迈克尔反应和碘介导的环化反应进行辅助。以 5-methyl-2,4-dihydro-3 H -pyrazol-3-one 作为亚甲基源，得到的最终产物是螺二氢呋喃吡唑羟基吲哚，而 1 H -indene -1,3( 2H )-dione 作为亚甲基来源得到最终化合物螺环丙基羟吲哚。两种螺环系统都获得了适度到良好的产率。