The results from this study demonstrate the potential of an AlGaN/GaN high electron mobility transistor sensor for the detection of reactive and transient biological molecules such as hydrogen peroxide. A boronate-based fluorescent probe was used with this device to detect the presence of micromolar levels of hydrogen peroxide typically associated with intracellular processes. The real-time electrical response of the high electron mobility transistor sensor showed a gradual decrease in the two-dimensional electron gas current as the reaction proceeded over time. A corresponding increase in the emission intensity was measured from the fluorescent probe with the progression of the reaction. The fluorescence from the boronate probe was used as an indicator to confirm the detection of hydrogen peroxide. These results demonstrate the dynamic measurement capability of AlGaN/GaN high electron mobility transistor sensors in monitoring real-time reactions of reactive oxygen species such as hydrogen peroxide.

这项研究的结果证明了 AlGaN/GaN 高电子迁移率晶体管传感器在检测反应性和瞬态生物分子（如过氧化氢）方面的潜力。该装置使用基于硼酸盐的荧光探针来检测通常与细胞内过程相关的微摩尔水平的过氧化氢的存在。高电子迁移率晶体管传感器的实时电响应显示随着反应的进行，二维电子气电流逐渐减小。随着反应的进行，荧光探针的发射强度相应增加。来自硼酸盐探针的荧光用作确认检测到过氧化氢的指示剂。