The zinc finger proteins make up a significant part of the proteome and perform a huge variety of functions in the cell. The CCCH-type zinc finger proteins have gained attention due to their unusual ability to interact with RNA and thereby control different steps of RNA metabolism. Since virus infections interfere with RNA metabolism, dynamic changes in the CCCH-type zinc finger proteins and virus replication are expected to happen. In the present review, we will discuss how three CCCH-type zinc finger proteins, ZC3H11A, MKRN1, and U2AF1, interfere with human adenovirus replication. We will summarize the functions of these three cellular proteins and focus on their potential pro- or anti-viral activities during a lytic human adenovirus infection.

中文翻译：

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CCCH型锌指蛋白在人类腺病毒感染中的作用

锌指蛋白构成蛋白质组的重要组成部分，并在细胞中执行多种功能。CCCH型锌指蛋白因其与RNA相互作用的异常能力而受到关注，从而控制了RNA代谢的不同步骤。由于病毒感染会干扰RNA代谢，因此有望发生CCCH型锌指蛋白的动态变化和病毒复制。在本文中，我们将讨论三种CCCH型锌指蛋白ZC3H11A，MKRN1和U2AF1如何干扰人腺病毒的复制。我们将总结这三种细胞蛋白的功能，并着重于在溶解性人类腺病毒感染过程中它们潜在的前病毒或抗病毒活性。