The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep 1 . These changes require precise homeostatic control by subcortical neuromodulatory structures 2 . The underlying mechanisms of this phenomenon, however, remain unknown. Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network events through phasic pontine waves known as pontogeniculooccipital waves (PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially, selectively influencing high-frequency ripples and low-frequency theta events, respectively. The two types of PGO wave are associated with opposite hippocampal spike-field coupling, prompting periods of high neural synchrony of neural populations during periods of ripple and theta instances. The coupling between PGO waves and ripples, classically associated with distinct sleep stages, supports the notion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transients may promote systems and synaptic memory consolidation as well as synaptic homeostasis. Studies using multi-structure recordings in macaque monkeys show that distinct phasic pontogeniculooccipital waves modulate hippocampal network events similar to those that underlie the learning and formation of memories during sleep.

中文翻译：

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海马θ和波纹与脑桥枕波的耦合

海马体在编码和巩固长期记忆方面发挥着重要作用，并在睡眠期间发生可塑性变化 1 。这些变化需要通过皮层下神经调节结构 2 进行精确的稳态控制。然而，这种现象的潜在机制仍然未知。在这里，使用猕猴的多结构记录，我们表明脑干通过称为 pontogeniculooccipital 波 (PGO 波) 的相位桥脑波瞬时调节海马网络事件。两种生理上不同类型的 PGO 波似乎依次发生，分别选择性地影响高频波纹和低频 theta 事件。这两种 PGO 波与相反的海马棘波场耦合有关，在涟漪和θ实例期间促使神经群体的高度神经同步期。PGO 波和涟漪之间的耦合，通常与不同的睡眠阶段相关，支持这样一种观点，即通过胆碱能桥脑瞬变的海马睡眠动力学的全局协调机制可以促进系统和突触记忆巩固以及突触稳态。在猕猴中使用多结构记录的研究表明，不同的阶段性脑桥枕波调节海马网络事件，类似于睡眠期间学习和记忆形成的基础。支持通过胆碱能桥脑瞬变的海马睡眠动力学的全局协调机制可以促进系统和突触记忆巩固以及突触稳态的观点。在猕猴中使用多结构记录的研究表明，不同的阶段性脑桥枕波调节海马网络事件，类似于睡眠期间学习和记忆形成的基础。支持通过胆碱能桥脑瞬变的海马睡眠动力学的全局协调机制可以促进系统和突触记忆巩固以及突触稳态的观点。在猕猴中使用多结构记录的研究表明，不同的阶段性脑桥枕波调节海马网络事件，类似于睡眠期间学习和记忆形成的基础。