Carbonized iodine-doped particles (CIPs) were developed to overcome the disadvantages of computed tomography (CT) contrast agents, such as high osmolality and the radiodensity dilution of monomolecular contrast agents and low solubility and high toxicity of polymeric contrast agents. The CIPs were synthesized via a hydrothermal synthesis for 8 h using ATIPA (5-amino-2,4,6-triiodoisophthalic acid), glycerol, and tromethamine in the presence of D.W. (deionized water)-insoluble ATIPA converted into CIPs through a hydrothermal synthesis, showing high solubility and low osmotic pressure. The in vitro contrast effect determined for the resulting CIPs demonstrated a 57.6% enhancement compared to iohexol, and the osmotic pressure of the resulting CIPs was lower than that of iohexol. In addition, the CIPs demonstrated no dilution-induced contrast decrease in plasma and, therefore, demonstrated high contrast strength in vivo. Cytotoxicity tests, hemolysis assays, and histological analyses were conducted to verify the biocompatibility of the CIP product; however, no toxicity was observed. Furthermore, the CIP demonstrated a much higher contrast effect than iohexol at low concentrations. These results indicate that the CIP we have produced may be used as an effective blood pool agent for CT imaging.

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不溶性三碘苯方便地水热合成碘掺杂的层析成像造影剂

为了克服计算机断层摄影（CT）造影剂的缺点，例如高渗透压和单分子造影剂的放射密度稀释以及聚合造影剂的低溶解度和高毒性，开发了碳化碘掺杂颗粒（CIP）。在不溶于DW（去离子水）的ATIPA存在下，通过水热将ATIPA（5-氨基-2,4,6-三碘间苯二甲酸），甘油和三甲胺通过水热合成8小时来合成CIP。合成，显示高溶解度和低渗透压。在体外与碘海醇相比，针对所得CIP确定的对比效果显示出57.6％的增强，并且所得CIP的渗透压低于碘海醇。另外，CIPs在血浆中没有显示出稀释引起的对比度降低，因此，在体内显示出高的对比度强度。进行了细胞毒性测试，溶血分析和组织学分析，以验证CIP产品的生物相容性；但是，未观察到毒性。此外，CIP在低浓度下显示出比碘海醇更高的对比效果。这些结果表明，我们生产的CIP可用作CT成像的有效血池药物。