The urinary excretion and wound retention data collected after a Pu-contaminated wound were analyzed using Markov Chain Monte Carlo (MCMC) to obtain the posterior distribution of the intakes and doses. An empirical approach was used to model the effects of medical treatments (chelation and excision) on the reduction of doses. It was calculated that DTPA enhanced the urinary excretion, on average, by a factor of 17. The empirical analysis also allowed calculation of the efficacies of the medical treatments-excision and chelation averted approximately 76% and 5.5%, respectively, of the doses that would have been if there were no medical treatment. All bioassay data are provided in the appendix for independent analysis and to facilitate the compartmental modeling approaches being developed by the health physics community.

中文翻译：

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238Pu污染的带有螯合和切除的伤口病例的剂量评估。

使用马氏链蒙特卡洛（MCMC）分析经Pu污染的伤口后收集的尿排泄和伤口保留数据，以获取摄入量和剂量的后验分布。使用经验方法来模拟药物治疗（螯合和切除）对减少剂量的影响。据计算，DTPA可使尿排泄平均增加17倍。经验分析还可以计算出药物治疗的功效，即切除和螯合分别避免了约76％和5.5％的剂量。如果没有治疗的话，本来可以的。附录中提供了所有生物测定数据，以进行独立分析，并促进健康物理学界正在开发的隔室建模方法。