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Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2020-11-17 , DOI: 10.1002/adsc.202000984
Zvjezdana Findrik Blažević 1 , Nevena Milčić 1 , Martina Sudar 1 , Maja Majerić Elenkov 2
Affiliation  

At the moment, there are approx. 100 published papers investigating halohydrin dehalogenases from different aspects; enzymology, molecular biology and reactions they can catalyse. Unquestionably, these enzymes are of great importance and hold an immense potential due to the wide spectrum of different compounds that can be synthesized by their action. These compounds, such as chiral epoxides, β‐substituted alcohols, oxazolidinones etc., significantly enrich the chemist's toolbox and, moreover, open the possibility for the synthesis of even more complex compounds. Still, there are many unknowns, and it is the purpose of this work to demonstrate the possibilities and bottlenecks, in scientific sense, that could further help in broadening the applicative potential of these fascinating enzymes.

中文翻译:

卤代醇脱卤酶及其在工业中的应用潜力-酶反应工程学的一个观点

目前,大约有 发表100篇论文,从各个方面研究卤代醇脱卤酶;酶,分子生物学及其可以催化的反应。毫无疑问,由于可以通过它们的作用合成的不同化合物的范围很广,这些酶非常重要并且具有巨大的潜力。这些化合物,例如手性环氧化物,β-取代的醇,恶唑烷酮等,极大地丰富了化学家的工具箱,而且为合成更复杂的化合物提供了可能性。尽管如此,仍有许多未知数,这项工作的目的是从科学的意义上证明可能性和瓶颈,以进一步帮助扩大这些引人入胜的酶的应用潜力。
更新日期:2021-01-19
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