Plant nucleotide‐binding, leucine‐rich repeat receptors (NLRs) perceive pathogen avirulence effectors and activate defense responses. Nucleotide‐binding, leucine‐rich repeat receptors are classified into coiled‐coil (CC)‐containing and Toll/interleukin‐1 receptor (TIR)‐containing NLRs. Recent advances suggest that NLR CC domains often function in signaling activation, especially for induction of cell death. In this review, we outline our current understanding of NLR CC domains, including their diversity/classification and structure, their roles in cell death induction, disease resistance, and interaction with other proteins. Furthermore, we provide possible directions for future work.

中文翻译：

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植物NLR免疫受体卷曲螺旋结构域的多样性，结构和功能

植物核苷酸结合，富含亮氨酸的重复受体（NLR）感知病原体的无毒力效应物并激活防御反应。结合核苷酸的富含亮氨酸的重复受体分为含有卷曲螺旋（CC）和含有Toll /白介素1受体（TIR）的NLR。最近的进展表明，NLR CC域通常在信号激活中起作用，尤其是在诱导细胞死亡方面。在这篇综述中，我们概述了我们对NLR CC域的当前理解，包括它们的多样性/分类和结构，它们在细胞死亡诱导，疾病抗性中的作用以及与其他蛋白质的相互作用。此外，我们提供了未来工作的可能方向。