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Physiological variation of the vertebral bone marrow water T2 relaxation time
NMR in Biomedicine ( IF 2.9 ) Pub Date : 2020-11-17 , DOI: 10.1002/nbm.4439
Stefan Ruschke 1 , Jan Syväri 1 , Michael Dieckmeyer 2 , Daniela Junker 1 , Marcus R Makowski 1 , Thomas Baum 2 , Dimitrios C Karampinos 1
Affiliation  

The aim of this study was to investigate physiological variations of the water T2 relaxation time in vertebral bone marrow with respect to age, body mass index (BMI), sex and proton density fat fraction (PDFF) based on single‐voxel magnetic resonance spectroscopy (MRS) at 3 T. Multi‐TE single‐voxel STEAM MRS data of a single lumbar vertebra (L4 or L5) from 260 subjects (160/100 female/male, age: 0.7/37.1/77.7 years, BMI: 13.6/26.2/44.5 kg/m2 [min./median/max.]) with no history of vertebral bone marrow pathologies were retrospectively included. All data were processed using a joint series T2‐constrained time domain‐based water–fat model. Water T2 and PDFF data were analyzed using (a) Pearson's correlation r and (b) multiple linear regression without interactions of the independent variables. Min./median/max. water T2 and PDFF were 11.2/21.1/42.5 ms and 4.0%/36.8%/82.0%, respectively. Pearson's correlation coefficients were significant (P < .05) for water T2 versus age (r = −0.429/−0.210 female/male) and for water T2 versus PDFF (r = −0.580/−0.546 female/male) for females and males, respectively. Females showed significant higher water T2 values compared with males (P < .001). Multiple linear regression for water T2 without interactions revealed a R2 = 0.407 with PDFF (P < .001) and sex (P < .001) as significant predictors. The current study suggests that under physiological conditions vertebral bone marrow water T2 is negatively correlated with age and PDFF and shows significant differences between females and males. The observed systematic trends are of relevance for the evaluation of T2 values and T2‐weighted bone marrow parameters. Further research on the exact mechanisms and drivers of the observed water T2 behavior is required.

中文翻译:

椎体骨髓水T2舒张时间的生理变化

本研究的目的是基于单体素磁共振波谱研究椎骨骨髓中水 T2 弛豫时间随年龄、体重指数 (BMI)、性别和质子密度脂肪分数 (PDFF) 的生理变化。 MRS) 在 3 T。来自 260 名受试者(160/100 女性/男性,年龄:0.7/37.1/77.7 岁,BMI:13.6/26.2)的单个腰椎(L4 或 L5)的 Multi-TE 单体素 STEAM MRS 数据/44.5 公斤/米2[min./median/max.]) 没有椎骨骨髓病变史被回顾性地包括在内。所有数据均使用基于联合序列 T2 约束时域的水脂模型进行处理。使用 (a) Pearson 相关 r 和 (b) 多元线性回归分析水 T2 和 PDFF 数据,没有自变量的相互作用。最小值/中值/最大值 水 T2 和 PDFF 分别为 11.2/21.1/42.5 ms 和 4.0%/36.8%/82.0%。对于女性和男性,水 T2 与年龄(r = -0.429/-0.210 女性/男性)和水 T2 与 PDFF(r = -0.580/-0.546 女性/男性)的Pearson 相关系数是显着的(P < .05), 分别。与男性相比,女性表现出显着更高的水 T2 值(P< .001)。没有相互作用的水 T2 的多元线性回归显示 R 2 = 0.407,PDFF ( P < .001) 和性别 ( P < .001) 作为重要预测因子。目前的研究表明,在生理条件下,椎体骨髓水 T2 与年龄和 PDFF 呈负相关,并且在女性和男性之间表现出显着差异。观察到的系统趋势与 T2 值和 T2 加权骨髓参数的评估相关。需要进一步研究观察到的水 T2 行为的确切机制和驱动因素。
更新日期:2021-01-04
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