We report the Pd(II)‐catalyzed picolinamide‐aided ortho‐C−H arylation‐, alkylation‐, and halogenation (sp² γ−C−H functionalization) of phenylglycinol substrates. Phenylglycinols are remarkable building blocks and have found different applications in synthetic organic and medicinal chemistry. This work is a contribution towards the expansion of the library of phenylglycinol scaffolds and also substrate scope development by using the Pd(II)‐catalyzed bidentate directing group picolinamide‐aided C−H activation tactic.

中文翻译：

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Pd（II）催化，吡啶甲酰胺辅助的sp2γ-CHF苯甘醇功能化：进入γ-CH酰化，烷基化和卤代的苯基甘醇支架

我们报告的钯（II） -催化的吡啶甲酰胺辅助邻-C-H arylation-，alkylation-，和卤化（SP ² γ苯基甘氨醇基板的-C-H官能化）。苯甘氨醇是非凡的组成部分，在合成有机和药物化学中发现了不同的应用。这项工作是通过使用Pd（II）催化的二齿酸引导的吡咯啉酰胺辅助的CH活化策略来扩大苯基甘醇支架文库以及开发底物范围的。