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A systematic review and meta-analysis of Hymenolepis nana in human and rodent hosts in Iran: A remaining public health concern
Comparative Immunology, Microbiology and Infectious Diseases ( IF 2 ) Pub Date : 2020-11-18 , DOI: 10.1016/j.cimid.2020.101580
Fatemeh Goudarzi , Sina Mohtasebi , Aref Teimouri , Yonas Yimam , Peyman Heydarian , Ghodratollah Salehi Sangani , Mohammad Javad Abbaszadeh Afshar

Hymenolepis nana, as a neglected zoonotic helminth, naturally occurs in both humans and rodents. Herein, a systematic review and meta-analysis was carried out to estimate pooled prevalence of H. nana infection among human and rodent hosts for the first time in Iran. PubMed, Web of Science, Scopus, and Embase databases (English articles) and SID and Magiran databases (Persian articles) were systematically searched for relevant studies published from inception till May 24, 2020. Chi2 and I2 index were used to assess the heterogeneity of the included studies. Publication bias was assessed using Egger's intercept and visual inspection of the funnel plot. Pooled prevalence was estimated using random-effects model with 95 % confidence interval (CI) and depicted as a forest plot. STATA software was used for analysis. The overall pooled prevalence estimate of H. nana in humans included 1.2 % (95 % CI = 1.0–1.4%). Subgroup analysis revealed 2.2 % (95 % CI = 1.8–2.6%) and 0.5 % (95 % CI = 0.3 to 0.8 %) of H. nana infection among school children and food handlers, respectively. In terms of rodent hosts, the overall pooled prevalence of H. nana infection included 13 % (95 % CI = 9.3–16.6%). Subgroup analysis revealed the highest rate of the infection was in Rattus spp. (19.6 %; 95 % CI = 10.6–28.6%), a genus with synanthropic behavior. It seems, despite the advancement in sanitation infrastructure and hygiene status, the H. nana infection compares to other helminthic diseases remains a challenging public health problem in Iran.



中文翻译:

对伊朗人类和啮齿动物宿主中膜蛙的系统评价和荟萃分析:仍然存在的公共卫生问题

膜被膜虫是一种被忽视的人畜共患蠕虫,它自然存在于人类和啮齿动物中。在这里,进行了系统的审查和荟萃分析,以估计在伊朗首次在人类和啮齿动物宿主中汇总的H. nana感染率。系统搜索了PubMed,Web of Science,Scopus和Embase数据库(英文文章)以及SID和Magiran数据库(波斯语文章)从开始到2020年5月24日发表的相关研究。Chi 2和I 2指数用于评估纳入研究的异质性。使用Egger的截距和漏斗图的目视检查来评估出版偏倚。使用具有95%置信区间(CI)的随机效应模型估算汇总患病率,并以森林图表示。使用STATA软件进行分析。人体中H. nana的总体合并患病率估计值包括1.2%(95%CI = 1.0-1.4%)。亚组分析显示,在学童和食品从业人员中,分别有2.2%(95%CI = 1.8–2.6%)和0.5%(95%CI = 0.3至0.8%)的H. nana感染。在啮齿动物的主机而言,整体汇集的流行绦虫感染占13%(95%CI = 9.3-16.6%)。亚组分析显示,最高的感染率是在Rattus spp中。(19.6%; 95%CI = 10.6-28.6%),是具有合人类行为的属。似乎,尽管卫生基础设施和卫生状况有所改善,但伊朗的纳纳氏菌感染与其他蠕虫病相比仍是一个充满挑战的公共卫生问题。

更新日期:2020-12-01
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