Motivated by the “self-seeding” of the cancer cells, the EPR-independent nanoparticles (NPs)-based therapeutic strategy have been explored to prevent hepatocellular carcinoma metastasis in this paper, the mechanism of anti-metastasis of the NPs was also evaluated. We firstly have established an aggressive whole-body spreading orthotopic LM3 tumour model closing to actual cases of human patients and the synthesized Trojan Horse-like amphiphilic nanobowls have been engineered with dual drugs with completely different pharmacokinetic profiles for cancer cell-mediated anti-metastasis therapy. These Trojan Horse-like nanobowls can serve as dual-drug delivery depots for site-specific pH/NIR dual-stimuli drug release with effectively suppressed primary tumor growth and metastases. Furthermore, the multi-mode UCL/MR/CT imaging is competent for providing comprehensive and valuable information for evaluating and adjusting the treatment. The employ of cancer cell-mediated anti-metastasis therapeutic strategy delivering drugs into metastatic cells to defeat tumor metastases provides directions in the fields of anti-metastasis therapy.

在癌细胞的“自我播种”的推动下，本文探索了基于EPR的纳米颗粒（NPs）独立治疗策略，以预防肝细胞癌转移，并评估了NPs的抗转移机制。我们首先建立了一个逼真的全身扩散性LM3恶性肿瘤模型，以接近人类患者的实际病例，并使用具有完全不同药代动力学特征的双重药物对合成的Trojan Horse样两亲纳米碗进行了工程改造，以用于癌细胞介导的抗转移疗法。这些特洛伊木马状纳米碗可作为双重药物递送库，用于特定位置的pH / NIR双重刺激药物释放，并有效抑制原发性肿瘤的生长和转移。此外，多模式UCL / MR / CT成像能够为评估和调整治疗提供全面而有价值的信息。癌细胞介导的抗转移治疗策略的使用将药物输送到转移细胞中以克服肿瘤转移，为抗转移治疗领域提供了方向。