当前位置: X-MOL 学术Rare Met. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Fe3O4@Angelica sinensis polysaccharide nanoparticles as an ultralow-toxicity contrast agent for magnetic resonance imaging
Rare Metals ( IF 8.8 ) Pub Date : 2020-11-18 , DOI: 10.1007/s12598-020-01620-0
Kai Wang , Xiao-Guang Xu , Ying-Li Ma , Chun-Rui Sheng , Li-Na Li , Li-Ying Lu , Jian Wang , Yi-Ning Wang , Yong Jiang

Although iron oxide (Fe3O4) nanoparticles have broad application prospects as magnetic resonance imaging (MRI) contrast agent, their biocompatibility and biotoxicity still need to be improved. In this study, we prepared Fe3O4@Angelica sinensis polysaccharide nanoparticles (Fe3O4@ASP NPs) with a 9 nm Fe3O4 core and ASP as the coating material. The Fe3O4@ASP NPs are superparamagnetic, can be taken up by liver and spleen macrophages in the circulatory system in vivo, and are a good-biocompatibility and low-toxicity transverse relaxation time (T2) and T2-star (T2*) magnetic resonance imaging (MRI) contrast agent for the liver. The cytotoxicity assessment using HeLa cells and the pathological tests in mice validate that Fe3O4@ASP NPs have low toxicity and good biocompatibility in vivo, which can be attributed to the ASP as a natural polysaccharide with good biocompatibility and its function of protecting the liver. Fe3O4@ASP NPs are a potential new MRI contrast agent with high signal intensity in vivo.

中文翻译:

Fe3O4@当归多糖纳米粒子作为磁共振成像的超低毒性造影剂

尽管氧化铁(Fe3O4)纳米粒子作为磁共振成像(MRI)造影剂具有广阔的应用前景,但其生物相容性和生物毒性仍有待提高。在这项研究中,我们制备了 Fe3O4@当归多糖纳米粒子 (Fe3O4@ASP NPs),其核心为 9 nm Fe3O4,ASP 作为涂层材料。Fe3O4@ASP NPs具有超顺磁性,可被体内循环系统中的肝脾巨噬细胞吸收,具有良好的生物相容性和低毒性的横向弛豫时间(T2)和T2-star(T2*)磁共振肝脏成像 (MRI) 造影剂。使用 HeLa 细胞进行细胞毒性评估和小鼠病理学测试证实 Fe3O4@ASP NPs 具有低毒性和良好的体内生物相容性,这可以归因于ASP作为一种天然多糖,具有良好的生物相容性和保护肝脏的功能。Fe3O4@ASP NPs 是一种潜在的新型 MRI 造影剂,在体内具有高信号强度。
更新日期:2020-11-18
down
wechat
bug