Background: Little is known about the patients’ view on treatment with medical cannabis (MC) for Parkinson’s disease (PD). Objective:To assess the PD community’s perception of MC and patients’ experience with MC. Methods:Applying a questionnaire-based survey, we evaluated general knowledge and interest in MC as well as the frequency, modalities, efficacy, and tolerability of application. Questionnaires were distributed nationwide via the membership journal of the German Parkinson Association and locally in our clinic to control for report bias. Results:Overall, 1.348 questionnaires (1.123 nationwide, 225 local) were analysed. 51% of participants were aware of the legality of MC application, 28% of various routes of administration (ROA) and 9% of the difference between delta9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). PD-related cannabis use was reported by 8.4% of patients and associated with younger age, living in large cities and better knowledge about the legal and clinical aspects of MC. Reduction of pain and muscle cramps was reported by more than 40% of cannabis users. Stiffness/akinesia, freezing, tremor, depression, anxiety and restless legs syndrome subjectively improved for more than 20% and overall tolerability was good. Improvement of symptoms was reported by 54% of users applying oral CBD and 68% inhaling THC-containing cannabis. Compared to CBD intake, inhalation of THC was more frequently reported to reduce akinesia and stiffness (50.0% vs. 35.4%; p < 0.05). Interest in using MC was reported by 65% of non-users. Conclusion:MC is considered as a therapeutic option by many PD patients. Nevertheless, efficacy and different ROA should further be investigated.

中文翻译：

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帕金森病中的大麻：患者的观点

背景：对于帕金森病（PD）患者对医用大麻（MC）治疗的看法知之甚少。目的：评估 PD 社区对 MC 的看法和患者对 MC 的体验。方法：采用基于问卷的调查，我们评估了对 MC 的一般知识和兴趣，以及应用的频率、方式、有效性和耐受性。问卷通过德国帕金森协会的会员期刊在全国范围内分发，并在我们的诊所本地分发，以控制报告偏差。结果：共分析问卷1.348份（全国1.123份，地方225份）。51% 的参与者知道 MC 应用的合法性，28% 的各种给药途径 (ROA) 和 9% 的 delta9-四氢大麻酚 (Δ9-THC) 和大麻二酚 (CBD) 之间的差异。8.4% 的患者报告了与 PD 相关的大麻使用，并且与年龄较小、生活在大城市以及对 MC 的法律和临床方面有更好的了解有关。超过 40% 的大麻使用者报告疼痛和肌肉痉挛减轻。僵硬/运动不能、僵硬、震颤、抑郁、焦虑和不安腿综合征主观改善20%以上，总体耐受性良好。54% 的用户报告了症状的改善，其中 54% 的用户使用了口服 CBD ，68% 的用户吸入了含 THC 的大麻。与 CBD 摄入量相比，据报道吸入 THC 可以减少运动不能和僵硬（50.0% 对 35.4%；p < 0.05）。65% 的非用户报告了对使用 MC 的兴趣。结论：MC 被许多 PD 患者视为一种治疗选择。尽管如此，