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Carbon Dots from Paeoniae Radix Alba Carbonisata: Hepatoprotective Effect
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2020-11-17 , DOI: 10.2147/ijn.s281976 Yusheng Zhao 1 , Yue Zhang 2 , Hui Kong 3 , Meiling Zhang 3 , Jinjun Cheng 3 , Jiashu Wu 3 , Huihua Qu 4 , Yan Zhao 3
International Journal of Nanomedicine ( IF 8 ) Pub Date : 2020-11-17 , DOI: 10.2147/ijn.s281976 Yusheng Zhao 1 , Yue Zhang 2 , Hui Kong 3 , Meiling Zhang 3 , Jinjun Cheng 3 , Jiashu Wu 3 , Huihua Qu 4 , Yan Zhao 3
Affiliation
Introduction: The charcoal processed product of Paeoniae Radix Alba (PRA), PRA Carbonisata (PRAC), has long been used for its hepatoprotective effects. However, the material basis and mechanism of action of PRAC remain unclear.
Aim: To explore the hepatoprotective effects of Paeoniae Radix Alba Carbonisata-derived carbon dots (PRAC-CDs).
Methods: PRAC-CDs were characterized using transmission electron microscopy, high-resolution transmission electron microscopy, ultraviolet, fluorescence, Fourier transform infrared and X-ray photoelectron spectroscopy, X-ray diffraction, and high-performance liquid chromatography. The hepatoprotective effect of PRAC-CDs was evaluated and confirmed using the classic carbon tetrachloride acute liver injury model.
Results: PRAC-CDs averaged 1.0– 2.4 nm in size and exhibited a quantum yield of 5.34% at a maximum excitation wavelength of 320 nm and emission at 411 nm. PRAC-CDs can reduce the ALT and AST levels of mice with carbon tetrachloride-induced acute liver injury and have a mitigating effect on the rise in TBA and TBIL. More interestingly, PRAC-CDs can significantly reduce MDA and increase SOD levels, demonstrating that PRAC-CDs can improve the body’s ability to scavenge oxygen free radicals and inhibit free radical-induced liver cell lipid peroxidation, thereby preventing liver cell damage.
Conclusion: These results demonstrate the remarkable hepatoprotective effects of PRAC-CDs against carbon tetrachloride-induced acute liver injury, which provide new insights into potential biomedical and healthcare applications of CDs.
Keywords: Paeoniae Radix Alba carbonisata, carbon dots, hepatoprotective
中文翻译：
白芍碳点：保肝作用
简介：白芍（PRA）的炭加工产品PRA Carbonisata（PRAC）因其保肝作用而被长期使用。然而，PRAC的物质基础和作用机制仍不清楚。
目的：探讨白芍衍生碳点（PRAC-CDs）的保肝作用。
方法：使用透射电子显微镜、高分辨率透射电子显微镜、紫外、荧光、傅里叶变换红外和 X 射线光电子能谱、X 射线衍射和高效液相色谱对 PRAC-CD 进行了表征。使用经典的四氯化碳急性肝损伤模型评估和确认 PRAC-CD 的保肝作用。
结果：PRAC-CD 的平均尺寸为 1.0-2.4 nm，在 320 nm 的最大激发波长和 411 nm 的发射波长下表现出 5.34% 的量子产率。PRAC-CDs 可以降低四氯化碳诱导的急性肝损伤小鼠的 ALT 和 AST 水平，并对 TBA 和 TBIL 的升高有缓解作用。更有趣的是，PRAC-CDs可以显着降低MDA，增加SOD水平，证明PRAC-CDs可以提高机体清除氧自由基的能力，抑制自由基诱导的肝细胞脂质过氧化，从而防止肝细胞损伤。
结论：这些结果表明 PRAC-CDs 对四氯化碳诱导的急性肝损伤具有显着的保肝作用，这为 CDs 的潜在生物医学和医疗保健应用提供了新的见解。
关键词： 白芍、碳点、保肝
更新日期：2020-11-17
Aim: To explore the hepatoprotective effects of Paeoniae Radix Alba Carbonisata-derived carbon dots (PRAC-CDs).
Methods: PRAC-CDs were characterized using transmission electron microscopy, high-resolution transmission electron microscopy, ultraviolet, fluorescence, Fourier transform infrared and X-ray photoelectron spectroscopy, X-ray diffraction, and high-performance liquid chromatography. The hepatoprotective effect of PRAC-CDs was evaluated and confirmed using the classic carbon tetrachloride acute liver injury model.
Results: PRAC-CDs averaged 1.0– 2.4 nm in size and exhibited a quantum yield of 5.34% at a maximum excitation wavelength of 320 nm and emission at 411 nm. PRAC-CDs can reduce the ALT and AST levels of mice with carbon tetrachloride-induced acute liver injury and have a mitigating effect on the rise in TBA and TBIL. More interestingly, PRAC-CDs can significantly reduce MDA and increase SOD levels, demonstrating that PRAC-CDs can improve the body’s ability to scavenge oxygen free radicals and inhibit free radical-induced liver cell lipid peroxidation, thereby preventing liver cell damage.
Conclusion: These results demonstrate the remarkable hepatoprotective effects of PRAC-CDs against carbon tetrachloride-induced acute liver injury, which provide new insights into potential biomedical and healthcare applications of CDs.
Keywords: Paeoniae Radix Alba carbonisata, carbon dots, hepatoprotective
中文翻译：
白芍碳点：保肝作用
简介：白芍（PRA）的炭加工产品PRA Carbonisata（PRAC）因其保肝作用而被长期使用。然而，PRAC的物质基础和作用机制仍不清楚。
目的：探讨白芍衍生碳点（PRAC-CDs）的保肝作用。
方法：使用透射电子显微镜、高分辨率透射电子显微镜、紫外、荧光、傅里叶变换红外和 X 射线光电子能谱、X 射线衍射和高效液相色谱对 PRAC-CD 进行了表征。使用经典的四氯化碳急性肝损伤模型评估和确认 PRAC-CD 的保肝作用。
结果：PRAC-CD 的平均尺寸为 1.0-2.4 nm，在 320 nm 的最大激发波长和 411 nm 的发射波长下表现出 5.34% 的量子产率。PRAC-CDs 可以降低四氯化碳诱导的急性肝损伤小鼠的 ALT 和 AST 水平，并对 TBA 和 TBIL 的升高有缓解作用。更有趣的是，PRAC-CDs可以显着降低MDA，增加SOD水平，证明PRAC-CDs可以提高机体清除氧自由基的能力，抑制自由基诱导的肝细胞脂质过氧化，从而防止肝细胞损伤。
结论：这些结果表明 PRAC-CDs 对四氯化碳诱导的急性肝损伤具有显着的保肝作用，这为 CDs 的潜在生物医学和医疗保健应用提供了新的见解。
关键词： 白芍、碳点、保肝
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