Kahn and colleagues (2020) highlight the underrecognized, modern epidemic of jaw shrinkage, including crowded teeth and constricted airways, but overlook a powerful explanatory variable: our pervasive exposures to developmental toxicants. In a landmark 2014 review on environmental causes for the epidemics of neurodevelopmental disorders, which affect 10%–15% of all US births, 11 common chemicals were recognized as neurodevelopmental toxicants (Grandjean and Landrigan 2014). Of these, we address mercury and fluoride. Both are systemic toxicants; they target certain molecular components having key roles in fundamental cellular processes—­including mineral assimilation, enzyme function, energy production, and gene expression. Both are particularly harmful during fetal and childhood development. Both have been used...

中文翻译：

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普遍存在，不安全地暴露于汞和氟化物，发展中的有毒物质，这些物质是颚病中生物上可能的致病因素。

卡恩和同事（2020年）突出了人们对下巴萎缩的认识不足的现代流行病，包括拥挤的牙齿和狭窄的气道，但忽略了一个强有力的解释变量：我们普遍接触到发育性毒物。在2014年的一项具有里程碑意义的评论中，神经发育障碍的流行病的环境成因影响了美国所有出生的10％至15％，其中11种常见化学物质被认为是神经发育毒物（Grandjean和Landrigan2014）。其中，我们涉及汞和氟化物。两者都是全身性毒物。它们靶向在基本细胞过程中起关键作用的某些分子成分，包括矿物质吸收，酶功能，能量产生和基因表达。两者在胎儿和儿童期发育中尤其有害。两者都被使用过...