The development of the induced pluripotent stem cells (iPSCs) technology has revolutionized the world on the establishment of pluripotent stem cells (PSCs) across a great variety of animal species. Generation of iPSCs from domesticated animals would provide unrestricted cell resources for the study of embryonic development and cell differentiation of these species, for screening and establishing desired traits for sustainable agricultural production, and as veterinary and preclinical therapeutic tools for animal and human diseases. Induced PSCs from domesticated animals thus harbor enormous scientific, economical, and societal values. Although much progress has been made toward the generation of PSCs from these species, major obstacles remain precluding the exclamation of the establishment of bona fide iPSCs. The most prominent of them remain the inability of these cells to silence exogenous reprogramming factors, the obvious reliance on exogenous factors for their self-renewal, and the restricted development potential in vivo. In this review, we summarize the history and current progress in domestic farm animal iPSC generation, with a focus on swine, ruminants (cattle, ovine, and caprine), horses, and avian species (quails and chickens). We also discuss the problems associated with the farm animal iPSCs and potential future directions toward the complete reprogramming of somatic cells from farm animals.

中文翻译：

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来自农场动物的诱导多能干细胞

诱导多能干细胞 ( iPSC ) 技术的发展彻底改变了世界建立多能干细胞 ( PSC)s) 跨越多种动物物种。从驯养动物中产生 iPSC 将为研究这些物种的胚胎发育和细胞分化、筛选和建立可持续农业生产所需的性状以及作为动物和人类疾病的兽医和临床前治疗工具提供不受限制的细胞资源。因此，来自驯化动物的诱导 PSC 具有巨大的科学、经济和社会价值。尽管在从这些物种产生 PSC 方面取得了很大进展，但仍然存在主要障碍，无法建立真正的PSC。iPSC。其中最突出的问题仍然是这些细胞无法抑制外源性重编程因子的沉默，其自我更新明显依赖于外源性因子，以及体内发育潜力受限。在这篇综述中，我们总结了家畜 iPSC 生成的历史和当前进展，重点是猪、反刍动物（牛、羊和山羊）、马和鸟类（鹌鹑和鸡）。我们还讨论了与农场动物 iPSC 相关的问题，以及对农场动物体细胞进行完全重编程的潜在未来方向。