The present study investigates Mg-SiO₂ nanocomposites as biodegradable implants for orthopedic and maxillofacial applications. The effect of presence and progressive addition of hollow silica nanoparticles (0.5, 1, and 1.5) vol.% on the microstructural, mechanical, degradation, and biocompatibility response of pure Mg were investigated. Results suggest that the increased addition of hollow silica nanoparticles resulted in a progressive increase in yield strength and ultimate compressive strength with Mg-1.5 vol.% SiO₂ exhibiting superior enhancement. The response of Mg-SiO₂ nanocomposites under the influence of Hanks’ balanced salt solution revealed that the synthesized composites revealed lower corrosion rates, indicating rapid dynamic passivation when compared with pure Mg. Furthermore, cell adhesion and proliferation of osteoblast cells were noticeably higher than pure Mg with the addition of 1 vol.% SiO₂ nanoparticle. The biocompatibility and the in vitro biodegradation of the Mg-SiO₂ nanocomposites were influenced by the SiO₂ content in pure Mg with Mg-0.5 vol.% SiO₂ nanocomposite exhibiting the best corrosion resistance and biocompatibility when compared with other nanocomposites. Enhancement in mechanical, corrosion, and biocompatibility characteristics of Mg-SiO₂ nanocomposites developed in this study are also compared with properties of other metallic biomaterials used in alloplastic mandibular reconstruction in a computational model.

本研究调查了Mg-SiO ₂纳米复合材料作为骨科和颌面应用的可生物降解植入物。研究了空心二氧化硅纳米颗粒（0.5、1和1.5）（体积）的存在和逐步添加对纯Mg的微观结构，机械，降解和生物相容性响应的影响。结果表明，中空二氧化硅纳米颗粒的增加的添加导致屈服强度和极限抗压强度的逐步提高，其中Mg-1.5vol。％的SiO ₂表现出优异的增强。Mg-SiO ₂的响应在Hanks平衡盐溶液的影响下，纳米复合材料显示出合成的复合材料显示出较低的腐蚀速率，与纯Mg相比，表明其具有快速的动态钝化作用。此外，通过添加1体积％的SiO ₂纳米颗粒，成骨细胞的细胞粘附和增殖明显高于纯Mg 。Mg-SiO ₂纳米复合材料的生物相容性和体外生物降解受到纯Mg中SiO ₂含量的影响，与其他纳米复合材料相比，Mg-0.5％（体积）的SiO ₂纳米复合材料表现出最佳的耐腐蚀性和生物相容性。Mg-SiO _2的机械，腐蚀和生物相容性特征的增强 在计算模型中，还将本研究中开发的纳米复合材料与用于同种异体下颌重建的其他金属生物材料的性能进行了比较。