To provide solid information about viral infection, disease, and body iron metabolism, the literature was surveyed for mutual correlations. Gender and age profiles of COVID-19 infection and disease correlate well with the profiles of serum iron and ferritin with correlation coefficients ≥ 0.75. There are further symptomatic hints that the ABO blood group system contributes to these correlations. Remarkably, the susceptibility to both the viral disease and iron dyshomeostasis can be traced back to the same gene loci of the ABO blood group system. The overlapping of susceptible gene loci together with the phenomenological correlations in gender and age are strong indicators for the interrelation of body iron dyshomeostasis with COVID-19 infection and disease.

中文翻译：

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COVID-19和人体铁：现象学和遗传相关性调查

为了提供有关病毒感染，疾病和体内铁代谢的可靠信息，对文献进行了相互关联性调查。COVID-19感染和疾病的性别和年龄特征与血清铁和铁蛋白的特征密切相关，相关系数≥0.75。有进一步的症状提示，ABO血型系统有助于这些相关性。值得注意的是，对病毒性疾病和铁稳态异常的敏感性都可以追溯到ABO血型系统的同一基因座。易感基因位点的重叠以及性别和年龄上的现象学相关性，是体内铁代谢异常与COVID-19感染和疾病之间相互关系的有力指标。