Reactive oxygen species (ROS)-responsive nanomedicine has been extensively developed to improve the therapeutic effects while reducing the systemic toxicity. ROS, as important biological metabolites and signaling molecules, are known to overexpress in most of tumors and inflammations. Among various ROS-sensitive moieties, phenylborate ester (PBAE) with easy modifiable structure and excellent biocompatibility, represents one of the most ROS-sensitive structures. To harness it as a switch, the past several years had witnessed a booming of ROS-sensitive PBAE-based nanomedicine for various medical purposes. Much of the efforts were devoted to exploiting the potential in the management of antitumor and anti-inflammation. This review first summarizes the design strategies of PBAE in the construction of nanomedicine, with PBAE acting as not only the ROS-responsive unit, but also the roles of hydrophobic backbone or bridging segment in the macromolecular structures. The ROS-responsive mechanisms are then briefly discussed. Afterward, we focus on the introduction of the state-of-the-art research on ROS-responsive PBAE-based nanomedicine for antitumor and anti-inflammation applications. The conclusion and future perspectives of ROS-responsive nanomedicine are also provided.

中文翻译：

---

ROS响应苯硼酸酯基纳米药物的设计策略及应用

已经广泛开发了对活性氧（ROS）敏感的纳米药物，以改善治疗效果，同时降低全身毒性。ROS作为重要的生物代谢产物和信号分子，在大多数肿瘤和炎症中均过表达。在各种ROS敏感部分中，具有易于修饰的结构和出色的生物相容性的苯硼酸酯（PBAE）代表了对ROS最敏感的结构之一。为了利用它来进行切换，过去几年见证了用于各种医疗目的的对ROS敏感的基于PBAE的纳米药物的蓬勃发展。许多努力致力于开发抗肿瘤和抗炎治疗的潜力。这篇综述首先总结了PBAE在纳米药物构建中的设计策略，PBAE不仅充当ROS响应单元，而且还充当大分子结构中疏水主链或桥联部分的作用。然后简要讨论了ROS响应机制。之后，我们专注于介绍针对抗肿瘤和抗炎症应用的基于ROS响应性PBAE的纳米药物的最新研究。还提供了ROS响应纳米医学的结论和未来展望。