Although mechanistic understanding of calcium signaling in bacteria remains inchoate, current evidence clearly links Ca²⁺ signaling with membrane potential and mechanosensation. Adopting a radically new approach, Luder et al. scanned the Keio collection of Escherichia coli gene knockouts (R. Luder, G. N. Bruni, and J. M. Kralj, J Bacteriol 203:e00509-20, 2021, https://doi.org/10.1128/JB.00509-20) to identify mutations that cause changes in Ca²⁺ transients. They identify genes associating Ca²⁺ signaling with outer membrane biogenesis, proton motive force, and, surprisingly, long-term DNA damage. Their work has major implications for electrophysiological communication between bacteria and their environment.

中文翻译：

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设置阶段：控制大肠杆菌中机械感觉和Ca2 +信号传导的基因

尽管对细菌中钙信号的机制了解仍然很少，但目前的证据清楚地表明Ca ²⁺信号与膜电位和机械感觉有关。Luder等人采用了一种全新的方法。扫描了大肠杆菌基因敲除的Keio集合（R.Luder，GN Bruni和JM Kralj，J Bacteriol 203：e00509-20，2021，https://doi.org/10.1128/JB.00509-20）以鉴定突变导致Ca ²⁺瞬态变化。他们确定了与Ca ²⁺信号传导与外膜生物发生，质子动力以及长期DNA损伤相关的基因。他们的工作对细菌与环境之间的电生理交流具有重要意义。