Staphylococcus epidermidis is a major cause of periprosthetic joint infection (PJI); its intracellular persistence within osteoblasts may compromise therapy if that therapy is not intracellularly active. The intracellular activity of rifampin, rifapentine, and rifabutin was assessed against five rifampin-susceptible and two rifampin-resistant S. epidermidis isolates. Compared to no treatment, treatment resulted in a ≥2-fold log₁₀ reduction of intracellular rifampin-susceptible, but not rifampin-resistant, S. epidermidis. These findings show activity of rifampin, rifapentine, and rifabutin against intraosteoblast PJI-associated S. epidermidis.

中文翻译：

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利福平，利福喷汀和利福布汀对细胞内毛周关节感染相关的表皮葡萄球菌具有活性

表皮葡萄球菌是假体周围关节感染（PJI）的主要原因。如果该疗法在细胞内不活跃，那么其在成骨细胞内的细胞内持久性可能会损害疗法。利福平，利福喷丁和利福布汀的细胞内活性针对五个易感利福平和两个耐利福平表皮葡萄球菌的菌株进行了评估。与不进行治疗相比，治疗可使易感利福平的细胞内表皮葡萄球菌减少≥2倍log ₁₀，但不耐利福平。这些发现表明利福平，利福喷丁和利福布丁对成骨细胞PJI相关表皮葡萄球菌的活性。