Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM.

中文翻译：

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fosM，从人菌群分离的细菌种类中鉴定出的新霉素抗性基因家族

磷霉素是已有数十年历史的抗生素，由于其对耐多药细菌的活性而被重新使用。在这里，我们使用了一种组合的体外/计算机模拟方法，以从人类微生物群中分离出25种新细菌，以寻找磷霉素抗性决定簇。推定的抗性基因被克隆到易感的大肠杆菌菌株中。MIC值从1μg/ ml增加到1,024μg/ ml。在这里，我们报道了一个新的潜在的磷霉素抗性基因家族，名为fosM。