This microreview focuses on the nucleophilic ring‐opening of azetidiniums presenting various substitution patterns at C2, C3, and C4. In most cases, the nucleophilic ring‐opening occurred in a stereoselective and regioselective fashion producing functionalized linear amines. Experimental selectivities associated with Density Functional Theory (DFT) calculations have allowed a better understanding of the parameters governing the regioselectivities.

中文翻译：

---

亲核试剂使氮杂环丁烷开环。多取代线性胺的合成

这篇微观综述重点关注在 C2、C3 和 C4 处呈现各种取代模式的氮杂环丁烷的亲核开环。在大多数情况下，亲核开环以立体选择性和区域选择性的方式发生，产生官能化的线性胺。与密度泛函理论 (DFT) 计算相关的实验选择性可以更好地理解控制区域选择性的参数。