Professional antigen‐presenting cells (APCs), which include dendritic cells (DCs) and monocytes are essential for inducing and steering adaptive T‐cell responses. Recent technological developments in single‐cell analysis have significantly advanced our understanding of APC subset heterogeneity. To accurately resolve this functional diversity and to account for tissue‐specific adaptation, novel phenotyping markers have been described more recently. While some of these largely overlap with traditionally used markers, more fine‐grained phenotyping might be essential during inflammatory settings, where the traditional distinction between monocytes and dendritic cells has become blurred. Within this phenotype report, we provide a concise overview of traditional and recently described markers for the phenotyping of DCs and monocytes in the human system.

中文翻译：

---

人类树突状细胞和单核细胞的综合表型分析

包括树突状细胞 (DC) 和单核细胞在内的专业抗原呈递细胞 (APC) 对于诱导和控制适应性 T 细胞反应至关重要。单细胞分析的最新技术发展显着提高了我们对 APC 子集异质性的理解。为了准确解决这种功能多样性并解释组织特异性适应，最近已经描述了新的表型标记。虽然其中一些与传统使用的标记物在很大程度上重叠，但在炎症环境中，更细粒度的表型可能是必不可少的，在这种情况下，单核细胞和树突状细胞之间的传统区别已经变得模糊。在这份表型报告中，我们简要概述了人类系统中 DC 和单核细胞表型的传统和最近描述的标记。