Synthetic efforts towards the total synthesis of the revised structure of marine macrolide palmerolide C is reported. Synthesis of the triol unit present in the C8,C9, C10 positions was achieved from d-ribose while Johnson orthoester rearrangement and a Wittig reaction were used to construct the C1–C7 component of the macrolactone. The key macrolactone unit was assembled using intermolecular Heck coupling reaction and Yamaguchi lactonization.

中文翻译：

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棕榈内酯C修饰结构的大内酯核的合成

据报道，对海洋大环内酯棕榈酰内酯C的修饰结构进行了全合成。存在于C8，C9，C10位置的三醇单元的合成是由d-核糖完成的，而Johnson Johnson原酸酯重排和Wittig反应用于构建大内酯的C1-C7组分。使用分子间的Heck偶联反应和山口内酯化组装关键的大内酯单元。