The molecular mechanisms that restore microglial quiescence after acute stimulation remain largely unexplored, unlike those that drive microglial activation. In this issue of Immunity, Shemer et al. discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow restoration of microglial quiescence after peripheral endotoxin challenge.

中文翻译：

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决斗二重奏：内毒素挑战小胶质细胞恢复中的IL10和TNF对抗。

与驱动小胶质细胞活化的那些分子机制不同，在急性刺激后恢复小胶质细胞静止的分子机制仍未得到充分探索。在本期《免疫》中，Shemer等人。发现小胶质细胞IL-10受体抵消了TNF的促炎作用，使外周内毒素激发后小胶质细胞恢复静止。