This paper reports a one-pot synthesis of 5-[2-(4-methoxyphenyl)ethyl]-1H-pyrazole-3-carboxylates via cyclocondensation of 1,1,1-trichloro-4-methoxy-6-(4-methoxyphenyl)hex-3-en-2-one with hydrazine hydrochloride in ROH (R = Me, Et, n-Pr, i-Pr, i-Bu, i-Am, hexadecyl) under conventional and microwave heating. Yields are comparable in both methods, but under MW heating the reaction proceeds faster. The antioxidant activity of the compounds was measured using DPPH radical scavenging assay. It was observed, that the increase of the alcohol chain length decreases the antioxidant potential of the raspberry ketone derived molecular system.

本文报道了通过1,1,1-三氯-4-甲氧基-6-（4-的环缩合反应一锅合成5- [2-（4-甲氧基苯基）乙基] -1 H-吡唑-3-羧酸酯在常规和微波加热下，在ROH（R ​​= Me，Et，n -Pr，i -Pr，i -Bu，i -Am，十六烷基）中与盐酸肼形成甲氧基苯基）hex-3-en-2-one 。两种方法的产率相当，但是在MW加热下，反应进行得更快。使用DPPH自由基清除测定法测量化合物的抗氧化活性。观察到，醇链长度的增加降低了覆盆子酮衍生的分子系统的抗氧化能力。