Abstract

Novel benzosuberone-quinazolinones hybrids have been synthesized efficiently in high yields, and their structures have been confirmed by¹H and ¹³C NMR, ESI-MS, and HRMS spectra. According to the in vitro tests of products for their antiproliferative activity against HeLa, MDA-MB-231, A549, and MIAPACA cancer cell lines, the compound 9b demonstrates significant cytotoxicity against A549 with GI₅₀ value 0.4 µM and compound 8a exhibits activity against MIAPACA with GI₅₀ value 0.6 µM.

中文翻译：

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新型苯并双氢萘醌-喹唑啉酮衍生物：合成和抗肿瘤活性

摘要

新型苯并亚砜-喹唑啉酮杂化物已得到高产高效合成，其结构已通过¹ H和¹³ C NMR，ESI-MS和HRMS光谱证实。根据产品它们对HeLa细胞，MDA-MB-231，A549，和MIAPACA癌细胞系的抗增殖活性的体外试验时，化合物9B展示了针对A549显著的细胞毒性与GI ₅₀值0.4μM和化合物8a中针对MIAPACA表现出活性GI ₅₀值为0.6 µM。