Superparamagnetic Fe₃O₄ nanoparticles have been synthesized using simple and ecofriendly hydrothermal method at supercritical conditions of ethanol. The morphology and crystal structure reveal cubic-like shape with an average size of 63 ± 30 nm and formation of FCC Fe₃O₄ phase structure. The magnetic properties exhibit superparamagnetic-like behavior at room temperature with saturation magnetization (Ms) of 108 emu/g and coercivity (HC) close to 0 Oe. The temperature dependence on magnetization measurements has confirmed the superparamagnetic behavior with blocking temperature T_B of 320 K at the therapeutic temperature range of hyperthermia therapy at 42–47 °C. Feasibility for magnetic hyperthermia has been tested under applied AC magnetic field and frequency ranges from 100 to 500 Oe and 147 to 304 kHz, respectively. The findings confirm that Fe₃O₄ nanoparticles are feasible for magnetic hyperthermia treatment of cancer.

在乙醇的超临界条件下，采用简单，环保的水热法合成了超顺磁性的Fe ₃ O ₄纳米粒子。形态和晶体结构显示为立方状，平均尺寸为63±30 nm，并形成了FCC Fe ₃ O ₄相结构。磁性在室温下表现出类似超顺磁性的行为，饱和磁化强度（Ms）为108 emu / g，矫顽力（HC）接近0 Oe。温度对磁化强度测量的依赖性已经证实了超顺磁行为具有阻断温度T _B在42–47°C的热疗治疗温度范围内达到320K。磁热疗的可行性已在施加的交流磁场下进行了测试，频率分别为100至500 Oe和147至304 kHz。这些发现证实了Fe ₃ O ₄纳米粒子对于磁热疗法治疗癌症是可行的。