当前位置: X-MOL 学术J. Clust. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Two Mixed-Ligand Co(II)-Based Coordination Polymers: Application Value in the Later Rehabilitation of Fracture Patients by Activating WNT Signaling Pathway
Journal of Cluster Science ( IF 2.8 ) Pub Date : 2020-11-17 , DOI: 10.1007/s10876-020-01936-y
Juan Shen , Yu-Jun Qi , Zheng-Hua Kan , Chuan-Hao Bi

Two coordination polymers containing Co(II) ions as the metal source have been prepared by the hydrothermal reaction, and their chemical formulae are {[Co(Hnbta)(bimm)](3H2O)}n (1) and {[Co1.5(nbta)(pyim)(H2O)](2H2O)}n (2) (pyim = N-(4-pyridylmethyl)imidazole, bimm = bis(imidazol-1-yl)methane and H3nbta = 5-nitro-1,2,3-benzenetricarboxylic acid) and. The application values of the new compound in the later rehabilitation of fracture patients were assessed and the detailed mechanism was investigated as well. First of all, the Vascular endothelial growth factor (VEGF) content and Fibroblast growth factor (FGF) content was evaluated with enzyme linked immunosorbent assay (ELISA) detection kit, and the results indicated compound 1 was much stronger than compound 2 on increasing the VEGF and FGF content. In addition to this, the activation levels of the Wingless-type (Wnt) signaling pathway in mesenchymal stem cells was followed by western blotting assay, the data suggested that compound 1 could up-regulated the activation levels of the Wnt signaling pathway.



中文翻译:

两种基于配体Co(II)的配位聚合物:通过激活WNT信号通路在骨折患者的后期康复中的应用价值

通过水热反应制备了两种以Co(II)离子为金属源的配位聚合物,其化学式为{[Co(Hnbta)(bimm)](3H 2 O)} n1)和{[Co 1.5(nbta)(pyim)(H 2 O)](2H 2 O)} n2)(pyim = N-(4-吡啶基甲基)咪唑,bimm =双(咪唑-1-基)甲烷和H 3nbta = 5-硝基-1,2,3-苯三羧酸)和。评估了新化合物在骨折患者后期康复中的应用价值,并研究了详细的机制。首先,用酶联免疫吸附试验(ELISA)检测试剂盒评估了血管内皮生长因子(VEGF)和成纤维细胞生长因子(FGF)的含量,结果表明化合物1在增加VEGF方面比化合物2强得多和FGF含量。除此之外,通过Western印迹法检测间充质干细胞中Wingless型(Wnt)信号通路的激活水平,数据表明化合物1可以上调Wnt信号通路的激活水平。

更新日期:2020-11-17
down
wechat
bug