当前位置: X-MOL 学术Appl. Nanosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Fabrication of graphene/gelatin/chitosan/tricalcium phosphate 3D printed scaffolds for bone tissue regeneration applications
Applied Nanoscience ( IF 3.869 ) Pub Date : 2020-11-17 , DOI: 10.1007/s13204-020-01615-4
Huigen Lu , Xuekang Pan , Minjie Hu , Jianqiao Zhang , Yefeng Yu , Xuqi Hu , Kai Jiang

The scaffold structures formed by the incorporation of reduced graphene oxide (RGO) nanomaterials can be studied to improve the 3D matrix properties in the applications of bone regeneration. On the other hand, RGO has delayed the incorporation into the mixtures that were determined to generate scaffolds on using 3D printing because of its poor colloidal stability of particles and weak solubility in water. Moreover, to produce RGO, the graphene oxide (GO) was treated with hydrazine hydrate solution, which was well known as a reducing agent that is highly hazardous. To outcome these drawbacks, an unique eco-friendly method was established to gather scaffolds that were 3D printed by the incorporation of RGO. This was obtained using the Gallic acid induced in situ reduction of the GO already existing on the gelatin/chitosan/tricalcium phosphate scaffolds. Moreover, scaffolds also exhibited antibacterial activity without conceding osteoblasts’ cell proliferation and viability. Furthermore, the obtained scaffolds showed good osteoblasts proliferation and viability indicating their possibility for applications in bone fracture healing.



中文翻译:

用于骨组织再生应用的石墨烯/明胶/壳聚糖/磷酸三钙3D打印支架的制造

可以研究通过掺入还原型氧化石墨烯(RGO)纳米材料形成的支架结构,以在骨骼再生应用中改善3D基质性能。另一方面,RGO由于其胶体稳定性差且在水中的溶解度较弱,因此延迟了使用3D打印确定生成支架的混合物的掺入。此外,为了生产RGO,用肼水合物溶液处理氧化石墨烯(GO),水合肼溶液是众所周知的高度危险的还原剂。为了解决这些缺点,建立了一种独特的生态友好方法来收集通过RGO合并3D打印的脚手架。这是利用没食子酸诱导的原位存在于明胶/壳聚糖/磷酸三钙支架上的GO还原而获得的。此外,支架还表现出抗菌活性,而不会降低成骨细胞的细胞增殖能力和活力。此外,所获得的支架显示出良好的成骨细胞增殖和生存能力,表明它们可用于骨折愈合中。

更新日期:2020-11-17
down
wechat
bug