Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

中文翻译：

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金基纳米材料在肿瘤光热疗法和化学疗法中的应用。

光热疗法（PTT）是一种微创肿瘤治疗方法，其中光热转化剂（PTA）可以通过外部光刺激在肿瘤组织中富集，从而将光子能量转化为热能以诱导肿瘤组织的温度高于正常生理温度，并且可以有效杀死肿瘤细胞和组织，同时避免损害健康组织。作为众所周知的生物相容性纳米材料，金基纳米材料具有高的光热转化效率和横截面，可以作为潜在的光热转化剂用于肿瘤靶向治疗。通过将修饰的化学治疗药物加载到金纳米材料的表面上，可以实现PTT与化学疗法的结合。因此，本文首先综述了金基纳米材料的制备及其表面功能化，如金纳米棒，金纳米星，金纳米壳等。其次，我们还介绍了金基纳米材料在PTT，化学疗法和联合疗法中的应用。最后，总结了金基光热转化剂的局限性和挑战，并展望了该领域的发展前景。