Liposome is a traditional drug-delivery system and most novel studies have focused on its drug release function. In this paper, a new drug-delivery system based on liposomes was prepared, which contains hydrophobic FeAg alloy nanoparticles (FeAgNPs) in their lipid bilayer and berberine as test drug in their middle water phase. The size of AgFe-Ls was about 200 nm, the encapsulation efficiency of drugs was 35% and the lower critical solution temperature (LCST) of AgFe-Ls was about 41.96 °C. FeAgNPs in the AgFe-Ls had a 1:1 iron-to-silver atomic ratio with both optical and superparamagnetic properties. The photothermal effect and magnetocaloric effect of FeAgNPs could serve up both photo-stimulated and magnetic- stimulated drug release to liposomes. Release experiments results showed that AgFe-Ls could easily release berberine when stimulated by UV light (45% drug release at 20 min) or alternating current electromagnetic field (AMF) (80% drug release at 4 h). AgFe-Ls with both photo-controlled and magnetic-controlled drug release functions are promising to serve up chemotherapy drugs to cancer cells.

中文翻译：

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使用磁刺激性和光刺激性脂质体为癌细胞提供化学治疗药物。

脂质体是传统的药物递送系统，大多数新的研究都集中在其药物释放功能上。本文制备了一种基于脂质体的新型药物递送系统，该系统在脂质双层中包含疏水性FeAg合金纳米颗粒（FeAgNPs），在中间水相中包含黄连素作为测试药物。AgFe-Ls的大小约为200 nm，药物的封装效率为35％，AgFe-Ls的较低临界溶液温度（LCST）为约41.96°C。AgFe-Ls中的FeAgNPs具有1：1的铁与银原子比，同时具有光学和超顺磁性。FeAgNPs的光热效应和磁热效应可以同时促进光刺激和磁刺激药物释放到脂质体。释放实验结果表明，AgFe-Ls在紫外光（20分钟释放45％药物）或交流电磁场（4小时释放80％）的刺激下可以轻易释放小碱。具有光控和磁控释药功能的AgFe-Ls有望为癌细胞提供化学治疗药物。