Amino acids are significant for human life and therefore considered as the crucial nutrients for human body with high biosafety. Due to their high biocompatibilities and various physicochemical properties, their polymers can be applied to construct drug delivery systems for various diseases' treatments. Among them, glioblastoma multiforme received special attention and numerous efforts regarding to nanotechnology were developed to treat such tumor. However, the biosafety of the delivering materials in those efforts arises as a critical issue in consideration of the weak patients. Therefore, a ROSresponsive nanoparticle (DOX@PLSPL) with poly(amino acids) encapsulating doxorubicin was developed for glioblastoma multiforme treatment. DOX@PLSPL was constructed by poly-lysine and poly-leucine with high biocompatibility. The high doxorubicin encapsulation efficiency and the controlled release manner of DOX@PLSPL ensured its high anti-tumor effect. Totally, this DOX@PLSPL can be used as a promising drug delivery system for glioblastoma multiforme treatments.

中文翻译：

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负载阿霉素的活性氧物种响应性聚氨基酸纳米颗粒，用于胶质母细胞瘤的多形治疗。

氨基酸对人类生命至关重要，因此被认为是具有高度生物安全性的人体关键营养素。由于它们的高生物相容性和各种理化特性，它们的聚合物可用于构建用于各种疾病治疗的药物输送系统。其中，多形性胶质母细胞瘤受到了特别的关注，并在纳米技术方面进行了许多努力来治疗这种肿瘤。然而，考虑到弱势患者，在这些努力中输送材料的生物安全性成为一个关键问题。因此，开发了一种多囊性胶质母细胞瘤的ROS响应纳米颗粒（DOX @ PLSPL），其具有包封阿霉素的聚氨基酸。DOX @ PLSPL由具有高生物相容性的聚赖氨酸和聚亮氨酸构建而成。阿霉素的高包封率和DOX @ PLSPL的控释方式确保了其高抗肿瘤作用。总的来说，这种DOX @ PLSPL可以用作多形性胶质母细胞瘤治疗的有希望的药物递送系统。