The gut microbiome plays a key role in animal health and metabolism through the intricate functional interconnection between the feed, gut microbes, and the host. Unfortunately, in aquaculture, the links between gut microbes and fish genetics and production phenotypes are not well understood. In this study, we investigate the associations between gut microbial communities, fish feed conversion, and fish genetics in the domestic Atlantic salmon. Microbial community composition was determined for 230 juvenile fish from 23 full-sib families and was then regressed on growth, carbon and nitrogen metabolism, and feed efficiency. We only found weak associations between host genetics and microbial composition. However, we did identify significant (p < 0.05) associations between the abundance of three microbial operational taxonomical units (OTUs) and fish metabolism phenotypes. Two OTUs were associated with both carbon metabolism in adipose tissue and feed efficiency, while a third OTU was associated with weight gain. In conclusion, this study demonstrates an intriguing association between host lipid metabolism and the gut microbiota composition in Atlantic salmon.

中文翻译：

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大西洋大西洋鲑鱼肠道菌群与代谢的关系

肠道微生物组通过饲料，肠道微生物和宿主之间的复杂功能互连，在动物健康和代谢中发挥关键作用。不幸的是，在水产养殖中，肠道微生物与鱼类遗传和生产表型之间的联系尚未得到很好的理解。在这项研究中，我们调查了国内大西洋鲑鱼肠道微生物群落，鱼饲料转化和鱼类遗传之间的关联。确定了来自23个全同胞科的230条幼鱼的微生物群落组成，然后根据其生长，碳和氮代谢以及饲料效率进行回归分析。我们仅发现宿主遗传学与微生物组成之间的弱关联。但是，我们确实确定了显着性（p <0。05）三种微生物操作分类单位（OTU）的丰度与鱼类代谢表型之间的关联。两个OTU与脂肪组织中的碳代谢和饲料效率相关，而第三个OTU与体重增加相关。总之，这项研究证明了大西洋鲑体内宿主脂质代谢与肠道菌群组成之间的紧密联系。