The immunosuppressive effects of regulatory B-cells (Bregs) and their immunosuppressive cytokines on immune responses in autoimmune disorders, mainly systemic lupus erythematosus (SLE), have been recently established. Therefore, the purpose of this article has been the exploration of the expressions of cytokines produced by B cells in newly diagnosed SLE patients. The findings demonstrated that the gene expression of IL-10, TGF-β, IL-35, PD-L1, and FasL was significantly up-regulated in SLE patients compared to healthy subjects (P < 0.05). Additionally, the results revealed that serum levels of IL-10, TGF-β, IL-35, PD-L1 were remarkably increased in patients with SLE compared to healthy subjects (P < 0.0001). However, serum levels of IL-10 and TGF-β decreased significantly with increasing SLEDAI score in studied patients (P < 0.05). It was concluded that the release of anti-inflammatory cytokines, particularly IL-10 and TGF-β, might inhibit immune responses and autoreactive immune cells in a compensatory manner in SLE patients with mild to moderate disease activity.

中文翻译：

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评估新诊断的系统性红斑狼疮患者免疫抑制细胞因子的表达：关注 B 细胞

最近确定了调节性 B 细胞 (Bregs) 及其免疫抑制细胞因子对自身免疫性疾病，主要是系统性红斑狼疮 (SLE) 免疫反应的免疫抑制作用。因此，本文的目的是探索B细胞产生的细胞因子在初诊SLE患者中的表达情况。研究结果表明，与健康受试者相比，SLE 患者中 IL-10、TGF-β、IL-35、PD-L1 和 FasL 的基因表达显着上调（P < 0.05）。此外，结果显示，与健康受试者相比，SLE 患者的血清 IL-10、TGF-β、IL-35、PD-L1 水平显着升高（P < 0.0001）。然而，随着研究患者 SLEDAI 评分的增加，IL-10 和 TGF-β 的血清水平显着降低（P < 0.05）。